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KMID : 0614620140640020093
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Korean Journal of Gastroenterology
2014 Volume.64 No. 2 p.93 ~ p.97
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Differences in the Prognosis according to the Periods of Diagnosis in Ulcerative Colitis
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Chae Hyun-Beom
Jung Yoon-Suk
Park Dong-Il
Lee Chang-Kyun
Huh Kyu-Chan
Shin Jeong-Eun
Kim Jae-Hak
Kim You-Sun
Jung Yun-Ho
Jung Sung-Ae
Song Hyun-Joo
Jang Hyun-Joo
Hong Sung-Noh
Kim Young-Ho
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Abstract
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Background/Aims: Infliximab was approved for the treatment of ulcerative colitis (UC) in 2006 and has recently been used as rescue therapy in steroid-refractory UC. The aim of this study was to investigate the differences of medication use and prognosis in UC patients according to the periods of diagnosis.
Methods: From 1987 to 2012, a total of 1,422 patients with UC were retrospectively reviewed in 12 hospitals. The study population was divided into two groups according to the periods of diagnosis as follows; group A: 1987-2005, group B: 2006-2012. Analyzed variables were compared by using chi-square test and logistic regression analysis.
Results: Mean age of the subjects was 42.2 years, and the mean follow-up period was 4.7 years. In univariate analysis, the use of infliximab in group B was significantly higher than group A (4.5% vs. 7.6%, p=0.016), and UC-related hospitalization (45.8% vs. 40.1%, p=0.031) and UC-related surgery (6.4% vs. 3.5%, p=0.010) in group B was significantly lower than that of group A. The use of oral steroid in surgery group was significantly higher than non-surgery group in multivariate analysis (OR 1.85, 95% CI 1.03-3.30, p=0.039).
Conclusions: Infliximab might play an important role for the treatment of steroid-refractory UC. Well-designed prospective trials based on the efficacy and safety of infliximab are required in the future.
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KEYWORD
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Ulcerative colitis, Infliximab, Steroid, refractory, Surgery
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